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KMID : 0811720040080000197
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Korean Journal of Physiology & Pharmacology
2004 Volume.8 No. 0 p.197 ~ p.0
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Effects of Nicotine on Cell Proliferation and Apoptosis in the Dentate Gyrus of Rats
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Jang Mi-Hyeon
Shin Min-Chul
Bahn Geon-Ho
Kim E-Hwa
Kim Chang-Ju
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Abstract
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Nicotine is a key neuroregulatory component of cigarette smoke. It has been shown that nicotine- self administration impairs hippocampal neuronal plasticity and suppresses neurogenesis. On the other hand, the possibility that nicotine may enhance learning ability and memory formation capability has been suggested. Controversy continues to this date regarding the effect of nicotine on learning ability and memory capabilities. In the present study, the effect of nicotine on cell proliferation and apoptosis in the dentate gyrus was investigated using 5-bromo-2?-deoxyuridine (BrdU) immunohistochemistry, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay, and caspase-3 immunohistochemistry. From the present results, it appears that nicotine at low doses enhances cell proliferation without altering the level of apoptosis in the dentate gyrus of the hippocampus; in contrast, nicotine at high doses appears to suppress cell proliferation and to increase apoptosis in the dentate gyrus. Nicotine thus seems to have opposite effects on cell proliferation and apoptosis in the dentate gyrus depending on the dose.
Source: Korean Journal of Physiology & Pharmacology.2004 Oct;8(Suppl I):S143-S143
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KEYWORD
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Nicotine, Cell proliferation, Apoptosis, Dentate gyrus
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